Arriving home from the ruins, Trish seems to be concerned with something. Dante asks her what's wrong. She thinks that the gun-like object Enzo discovered might be crafted by Machiavelli, a legendary demon gunsmith known in the demon world. According to Trish, if Sparda was known for his prowess with swords, Machiavelli was known as the best gunslinger in the demon world before his death. The guns crafted by Machiavelli were very popular among demons who could use guns, as they gave their users immense power. Having seen a catalog of his guns during her time in the demon world, Trish points out that Dante has some of his guns as well (likely referring to weapons such as Artemis). Trish is worried because if the relic was indeed a gun crafted by Machiavelli, Enzo could get in huge trouble since there are many demons looking to obtain it. Dante sighs but decides to look for Enzo nonetheless.
Enzo is seen negotiating the reward of the job with his client. The client is reluctant to give Enzo hazard pay which Enzo demanded. The agreement was to pay him extra if there were dangers involved, but Enzo claimed that there were no dangers only because his team was skilled so he still has the right to receive it. Seeing the client's reluctance, Enzo asks him to raise the reward in exchange for the relic he found in the ruins. The client is offended by Enzo's offer and refuses. However, at that moment, a demon break in through a window and kills the client, as well as his subordinates. The demon threatens Enzo to give him the gun, but he is panicked and thinks he's just having a nightmare. Enzo tries to hand off the gun, but then realizes that the gun is stuck to his hand for some reason. After expressing his disgust for mankind, the demon goes on to kill Enzo. Enzo, still not understanding what's going on, screams in fear and anger before a firing sound is heard.
Dante and Trish arrive on the scene, finding many people and the demon dead, but Enzo is mysteriously missing. Confused, Dante asks Trish if the gun could be used by humans, to which Trish responds she doesn't know since there are many variations. The only thing clear to them was that they needed to find Enzo as soon as possible.
Enzo, wandering around the city, still thinks this is a bad dream. He still refuses to believe that thing he saw was a demon. One of Enzo's friend sees him and talks to him, suggesting him drink at his place since he seems very unhappy about something. Enzo refuses, saying he's in no mood, but his friend kept trying to cheer him up. Enzo angrily shouts "Shut up!" and aims the gun at his friend. He threatens the confused friend, but his friend thought it was some kind of a toy and mockingly told him to try killing him with it. Enzo, not in right mind, tries to shoots at his friend. "Enzo!" Dante, upon seeing the scene, immediately fires at the gun Enzo is holding. To everyone's surprise, the bullet Dante shot was neutralized by Enzo for some reason. Trish speculates that since the gun considers Enzo to be his user, it is automatically reacting to protect his safety. He is surprised by the sudden gunshot but relieved to see Dante and Trish. They tell him to drop the gun, but he starts laughing sarcastically and then says it's stuck to his hand. Dante and Trish gasp as they realize his arm is beginning to be consumed by the demon gun. Trish recalls that one of the guns Machiavelli crafted had the ability to transform its user to a huge weapon. Considering Dante a threat, Machiavelli's demon gun starts firing at him. The bullets shot from the gun has a homing ability and actually wounds Dante. Enzo still does not understand what's going on but insists it wasn't him who shot Dante. Dante calls him an idiot and tells him that it was a doing of demons he never believes. Enzo, still refusing to believe demons exist, starts laughing hysterically and decides that this is a bad dream caused by drinking too much last night. "No hard feelings, Enzo." Believing it's now impossible to save Enzo unharmed, Dante slashes his sword. A painful sound is heard and the scene ends with Enzo's scream.
After what happened to Enzo, Trish decides to leave Dante's office because she wanted to travel around the world personally and find items from the underworld to prevent people from falling victim to devil arms. Dante does not stop Trish and agrees to let her go.Trish teases Dante by saying maybe she wants him to stop her. Dante snorts and says "I'm not the kind of guy who understands feelings of others." Trish then asks Dante a favor. "While I'm gone, can you change the name of the shop to what it was before?" She wanted him to change it because the name Devil Never Cry meant that they owned the shop together. Dante agrees, and Trish leaves.